Invention Grant
- Patent Title: Process for lactonization in the preparation of statins
- Patent Title (中): 内酯化制备他汀类药物的方法
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Application No.: US11574872Application Date: 2004-09-08
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Publication No.: US07678927B2Publication Date: 2010-03-16
- Inventor: Govind Singh , Paramvir Bhadwal , Sanjay Jaiswal , Dinesh R. Panchasara , Rajesh Kumar Thaper , Sushil Kumar Dubey , Jag Mohan Khanna
- Applicant: Govind Singh , Paramvir Bhadwal , Sanjay Jaiswal , Dinesh R. Panchasara , Rajesh Kumar Thaper , Sushil Kumar Dubey , Jag Mohan Khanna
- Applicant Address: IN Noida
- Assignee: Jubilant Organosys Limited
- Current Assignee: Jubilant Organosys Limited
- Current Assignee Address: IN Noida
- Agency: Workman Nydegger
- International Application: PCT/IN2004/000282 WO 20040908
- International Announcement: WO2006/027790 WO 20060316
- Main IPC: C07D309/30
- IPC: C07D309/30
Abstract:
The present invention relates to an improved and industrial friendly process for lactonization to produce compound of the Formula [I], from compound of the Formula [II] in presence of an inorganic compound as a suitable lactonizing agent, preferably alkali metal hydrogen sulfate, and crystallizing the obtained lactone product in a solvent; or treating compound of the Formula [II] in the presence of an inorganic compound preferably alkali metal hydrogen sulfate using phase transfer catalyst in heterogeneous phase followed by crystallizing the obtained lactone product in a solvent.
Public/Granted literature
- US20070265457A1 Process for Lactonization in the Preparation of Statins Public/Granted day:2007-11-15
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