发明授权
- 专利标题： Crystalline forms of antidiabetic compounds
- 专利标题（中）： 抗糖尿病化合物的结晶形式
-
申请号： US11885842申请日： 2006-03-10
-
公开(公告)号： US07683092B2公开(公告)日： 2010-03-23
- 发明人: Dalian Zhao , Jean-Francois Marcoux , David Boardman , Aquiles E. Leyes
- 申请人： Dalian Zhao , Jean-Francois Marcoux , David Boardman , Aquiles E. Leyes
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Richard C. Billups; Catherine D. Fitch
- 国际申请： PCT/US2006/008476 WO 20060310
- 国际公布： WO2006/099077 WO 20060921
- 主分类号： A61K31/404
- IPC分类号： A61K31/404 ; C07D209/18
摘要：
Novel crystalline forms of two indole compounds connected to phenoxyalkylcarboxylic acid groups are selective PPAR gamma partial agonists that are useful in the treatment of type 2 diabetes, hyperglycemia, obesity, dyslipidemia, and the metabolic syndrome. The novel crystal forms include a crystalline free acid dihydrate and crystalline free acid anhydrate of one compound and several crystalline forms of the free acid and the sodium salt of the second compound. The invention also relates to pharmaceutical compositions comprising these novel crystal forms, processes to prepare the crystal forms and their pharmaceutical compositions, and uses of the crystal forms in the treatment of type 2 diabetes and other PPAR gamma modulated diseases.
公开/授权文献
- US20080221198A1 Novel Crystalline Forms of Antidiabetic Compounds 公开/授权日：2008-09-11
信息查询
IPC分类:
