发明授权
- 专利标题： Pegylated factor VIII
- 专利标题（中）： 聚乙二醇化因子VIII
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申请号： US11729625申请日： 2007-03-29
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公开(公告)号： US07683158B2公开(公告)日： 2010-03-23
- 发明人: Juergen Siekmann , Katalin Varadi , Herbert Gritsch , Peter Turecek
- 申请人： Juergen Siekmann , Katalin Varadi , Herbert Gritsch , Peter Turecek
- 申请人地址： US IL Deerfield CH Wallisellen
- 专利权人： Baxter International Inc.,Baxter Healthcare
- 当前专利权人： Baxter International Inc.,Baxter Healthcare
- 当前专利权人地址： US IL Deerfield CH Wallisellen
- 代理机构： Marshall, Gerstein & Borun LLP
- 主分类号： C07K14/745
- IPC分类号： C07K14/745
摘要：
The invention is a proteinaceous construct comprising a Factor VIII molecule having at least a portion of the B domain intact, which is conjugated to a water-soluble polymer such as polyethylene glycol having a molecular weight of greater than 10,000 Daltons. The construct has a biological activity of at least 80% of the biological activity of native Factor VIII, and the in vivo half-life of the construct is increased by at least 1.5 fold as compared to the in vivo half-life of native factor FVIII.
公开/授权文献
- US20070244301A1 Pegylated factor VIII 公开/授权日：2007-10-18
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