发明授权
US07691856B2 Thiadiazoledioxides and thiadiazoleoxides as CXC- and CC-chemokine receptor ligands
失效
噻二唑二氧化物和噻二唑氧化物作为CXC-和CC-趋化因子受体配体
- 专利标题： Thiadiazoledioxides and thiadiazoleoxides as CXC- and CC-chemokine receptor ligands
- 专利标题（中）： 噻二唑二氧化物和噻二唑氧化物作为CXC-和CC-趋化因子受体配体
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申请号： US11651128申请日： 2007-01-09
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公开(公告)号： US07691856B2公开(公告)日： 2010-04-06
- 发明人: Arthur G. Taveras , Jianhua Chao , Purakkattle J. Biju , Younong Yu , Cynthia J. Aki , J. Robert Merritt , Ge Li , John J. Baldwin , Gaifa Lai , Minglang Wu , Evan A. Hecker
- 申请人： Arthur G. Taveras , Jianhua Chao , Purakkattle J. Biju , Younong Yu , Cynthia J. Aki , J. Robert Merritt , Ge Li , John J. Baldwin , Gaifa Lai , Minglang Wu , Evan A. Hecker
- 申请人地址： US NJ Kenilworth US NJ Cranbury
- 专利权人： Schering Corporation,Pharmacopeia, Inc.
- 当前专利权人： Schering Corporation,Pharmacopeia, Inc.
- 当前专利权人地址： US NJ Kenilworth US NJ Cranbury
- 代理商 Henry C. Jeanette
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; A61K31/4453 ; A61K31/5355 ; C07D285/06 ; C07D417/14
摘要：
Disclosed are novel compounds of the formula: and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, acute pain, acute and chronic inflammatory pain, and neuropathic pain using a compound of formula IA.