发明授权
- 专利标题： pH sensitive prodrugs of 2,6-diisopropylphenol
- 专利标题（中）： 2,6-二异丙基苯酚的pH敏感前药
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申请号： US11881143申请日： 2007-07-24
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公开(公告)号： US07691904B2公开(公告)日： 2010-04-06
- 发明人: Subramanian Marappan , Cris Davenport , Sepehr Sarshar
- 申请人： Subramanian Marappan , Cris Davenport , Sepehr Sarshar
- 申请人地址： US CA Vista
- 专利权人： Auspex Pharmaceuticals, Inc
- 当前专利权人： Auspex Pharmaceuticals, Inc
- 当前专利权人地址： US CA Vista
- 代理商 Dennis A. Bennett; Michael Sertic
- 主分类号： A61K31/165
- IPC分类号： A61K31/165 ; A61K31/216 ; C07C233/02 ; C07C69/712
摘要：
The present invention is directed to water-soluble derivatives of 2,6-diisopropylphenol (Propofol). The compounds act as prodrugs of 2,6-diisopropylphenol and metabolize rapidly to Propofol thereby providing an alternative to the water-insoluble 2,6-diisopropylphenol. Pharmaceutical compositions comprising these compounds, methods of induction and maintenance of anesthesia or sedation as well as methods of treating neurodegenerative diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
公开/授权文献
- US20080248093A1 pH sensitive prodrugs of 2,6-diisopropylphenol 公开/授权日：2008-10-09