发明授权
US07695910B2 Method for manufacturing hydrogel biochip by using star-like polyethylene glycol derivative having epoxy group
失效
通过使用具有环氧基团的星状聚乙二醇衍生物制造水凝胶生物芯片的方法
- 专利标题: Method for manufacturing hydrogel biochip by using star-like polyethylene glycol derivative having epoxy group
- 专利标题(中): 通过使用具有环氧基团的星状聚乙二醇衍生物制造水凝胶生物芯片的方法
-
申请号: US11510931申请日: 2006-08-28
-
公开(公告)号: US07695910B2公开(公告)日: 2010-04-13
- 发明人: Nam Huh , Mi-jung Song , Jong-myeon Park , Ga-young Park
- 申请人: Nam Huh , Mi-jung Song , Jong-myeon Park , Ga-young Park
- 申请人地址: KR
- 专利权人: Samsung Electronics Co., Ltd.
- 当前专利权人: Samsung Electronics Co., Ltd.
- 当前专利权人地址: KR
- 代理机构: Cantor Colburn LLP
- 优先权: KR2001-53687 20010901; KR2002-48128 20020814
- 主分类号: C12Q1/68
- IPC分类号: C12Q1/68 ; C12M1/36 ; G01N33/543
摘要:
A method for manufacturing a biochip and a biochip manufactured by the method are provided. In the biochip manufacturing method, a star-like polyethylene glycol derivative having an epoxy group at its terminal is reacted with a low molecular weight hydrophilic polymer to form a matrix, and a probe is covalently bound to the matrix and immobilized on a solid substrate. The biochip has a 3-dimensional structure where it spatially protrudes from its surface and improved chip sensitivity. In addition, the biochip can be conveniently and efficiently manufactured using an aqueous solution at low costs.