发明授权
- 专利标题： Phosphodiesterase 4 inhibitors
- 专利标题（中）： 磷酸二酯酶4抑制剂
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申请号： US10825610申请日： 2004-04-16
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公开(公告)号： US07696198B2公开(公告)日： 2010-04-13
- 发明人: Ashok Tehim , Allen Hopper , Ruiping Liu , Erik Kuester , Robert F. Dunn , Thomas E. Renau
- 申请人： Ashok Tehim , Allen Hopper , Ruiping Liu , Erik Kuester , Robert F. Dunn , Thomas E. Renau
- 申请人地址： US NJ Montvale
- 专利权人： Memory Pharmaceuticals Corporation
- 当前专利权人： Memory Pharmaceuticals Corporation
- 当前专利权人地址： US NJ Montvale
- 代理机构： Millen, White, Zelano, Branigan, P.C.
- 主分类号： A61K31/54
- IPC分类号： A61K31/54 ; A61K31/425 ; C07D417/02 ; C07D413/02 ; C07D405/00
摘要：
Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs. The compounds of the present invention are of formula I: wherein R1, R2, and R3 are as defined herein.
公开/授权文献
- US20050026913A1 Phosphodiesterase 4 inhibitors 公开/授权日：2005-02-03