In a network-based mail processing system and method of the invention, the originating presort bureau or node is defined as the first bureau to receive and process mail, usually near the point of creation. Each presort bureau or node in the network is generally also a destination bureau or node since each processes mail from other nodes for delivery to recipients in its respective region by the postal regional sorting centers associated with its destination codes. Interactive network processing enables higher density of sorts at destination nodes and reduces overall sorts, postage, and sort costs over non-interactive processing centers. The term “presort bureau” is used to connote a service bureau or any other entity which is a) part of the enterprise network, b) processes mail created and entered by itself or by mailers it services, and/or c) processes mail interactively with other network nodes. A similar network is described for mail-like items.