发明授权
- 专利标题： Method for producing polyol-IFN-β conjugate
- 专利标题（中）： 生产多元醇-IFF-的方法 缀合物
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申请号： US11674476申请日： 2007-02-13
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公开(公告)号： US07700314B2公开(公告)日： 2010-04-20
- 发明人: Nabil El-Tayar , Michael J. Roberts , Milton Harris , Wayne Sawlivich
- 申请人： Nabil El-Tayar , Michael J. Roberts , Milton Harris , Wayne Sawlivich
- 申请人地址： CH Coinsins, Vaud
- 专利权人： Merck Serono SA
- 当前专利权人： Merck Serono SA
- 当前专利权人地址： CH Coinsins, Vaud
- 代理机构： Browdy and Neimark, PLLC
- 主分类号： C12P21/00
- IPC分类号： C12P21/00 ; C08G65/08 ; C07K14/52
摘要：
PEG-IFN-β conjugates, where a PEG moiety is covalently bound to Cys17 of human IFN-β, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-β.