发明授权
- 专利标题: Amino heterocyclic modulators of chemokine receptor activity
- 专利标题(中): 趋化因子受体活性的氨基杂环调节剂
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申请号: US10589406申请日: 2005-02-08
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公开(公告)号: US07700772B2公开(公告)日: 2010-04-20
- 发明人: Lihu Yang , Alexander Pasternak , Sander G. Mills
- 申请人: Lihu Yang , Alexander Pasternak , Sander G. Mills
- 申请人地址: US NJ Rahway
- 专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人地址: US NJ Rahway
- 代理商 James L. McGinnis; Catherine D. Fitch
- 国际申请: PCT/US2005/003849 WO 20050208
- 国际公布: WO2005/080371 WO 20050901
- 主分类号: C07D401/04
- IPC分类号: C07D401/04 ; C07D407/04 ; A61K31/445 ; A61K31/438
摘要:
Compounds of Formula I and Formula II: (wherein n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, R17, R18, R19, R24, R25, R26, R27, R28, R29, R30, R33, R34, R35, R36, R37, R38, A, j, k, m, n, X, Y and Z are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.
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