A surge protection circuit includes a first surge absorber and a first conducting wire. The first surge absorber has an end electrically connected to a first power signal line. The first conducting wire is covered with insulating material and electrically connected to the other end of the first surge absorber and a second power signal line. The first surge absorber absorbs energy of a surge signal in a short-circuit state when the surge signal flows through the first power signal line or the second power signal line. Afterwards, the first conducting wire which is connected to the first surge absorber in series is damaged by the energy of the surge signal to enter an interrupted state, thereby protecting a signal processing device which is electrically connected to the first power signal line and the second power signal line.