发明授权
- 专利标题： ErbB4 antagonists
- 专利标题（中）： ErbB4拮抗剂
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申请号： US12215200申请日： 2008-06-24
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公开(公告)号： US07704498B2公开(公告)日： 2010-04-27
- 发明人: Mary E. Gerritsen , Mark X. Sliwkowski
- 申请人： Mary E. Gerritsen , Mark X. Sliwkowski
- 申请人地址： US CA South San Francisco
- 专利权人： Genentech, Inc.
- 当前专利权人： Genentech, Inc.
- 当前专利权人地址： US CA South San Francisco
- 代理商 Traci H. Ropp; James A. Fox; Ginger R. Dreger
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K39/00 ; C12P21/08 ; C07K16/18 ; C07K16/28
摘要：
The present invention concerns methods and means for controlling excessive proliferation and/or migration of smooth muscle cells, and in particular for treating stenosis, by using antagonists of a native ErbB4 receptor. The invention further concerns a method for the identification of ErbB4 agonists and antagonists capable of inhibiting or enhancing the proliferation or migration of smooth muscle cells.
公开/授权文献
- US20090068205A1 ErbB4 antagonists 公开/授权日：2009-03-12
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