发明授权
- 专利标题： Methods of identifying immunoregulatory agents, immunoregulatory agents, and uses thereof
- 专利标题（中）： 鉴定免疫调节剂，免疫调节剂及其用途的方法
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申请号： US10584837申请日： 2004-12-28
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公开(公告)号： US07704686B2公开(公告)日： 2010-04-27
- 发明人: Chikao Morimoto , Kei Ohnuma
- 申请人： Chikao Morimoto , Kei Ohnuma
- 申请人地址： JP Tokyo
- 专利权人： Toudai TLO, Ltd.
- 当前专利权人： Toudai TLO, Ltd.
- 当前专利权人地址： JP Tokyo
- 代理机构： Sterne, Kessler, Goldstein & Fox P.L.L.C.
- 国际申请： PCT/JP2004/019846 WO 20041228
- 国际公布： WO2005/063170 WO 20050714
- 主分类号： A61K48/00
- IPC分类号： A61K48/00
摘要：
The present invention provides methods of identifying a substance that down-regulates or up-regulates an immune response and kits used for the identification methods. A method of this invention comprises detecting a substance that inhibits or enhances the interaction between CD26 and caveolin-1. Another method comprises detecting a substance that inhibits or enhances the interaction between caveolin-1 and Tollip. Still another method comprises detecting a substance that inhibits or enhances the interaction among caveolin-1, Tollip, and IRAK-1. The present invention also relates to immunoregulatory agents comprising a substance that down-regulates an immune response, such as siRNA against caveolin-1 or Tollip. The invention further provides immunoregulatory agents comprising a substance that up-regulates an immune response. These agents are useful for treating inflammatory diseases, autoimmune diseases, or other immune-mediated disorders.
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