Methods of administering an injection are provided including methods of administering injections by individuals exhibiting deteriorated motor skills or impaired hand function. The method includes establishing a hand position about an injection device, including placing at least a one digit of a user' hand about the injection device and placing at least one other digit of a user's hand upon an actuator of the injection device. The hand position is substantially maintained while the injection device is manipulated and positioned to insert a needle at one end thereof into a portion of the user's skin. The hand position is substantially maintained while the user displaces the actuator of the injection device with the at least one other digit in a direction which is substantially transverse to an axis defined between a first end of the injection device and a second end of the device, the needle being located at the second end of the device.