发明授权
- 专利标题: Implantable device comprising phosphorus-containing macrolides
- 专利标题(中): 含有磷的大环内酯类植入装置
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申请号: US11650017申请日: 2007-01-05
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公开(公告)号: US07709020B2公开(公告)日: 2010-05-04
- 发明人: David L. Berstein , Leonard W. Rozamus , Yihan Wang , Chester A. Metcalf, III
- 申请人: David L. Berstein , Leonard W. Rozamus , Yihan Wang , Chester A. Metcalf, III
- 申请人地址: US MA Cambridge
- 专利权人: ARIAD Pharmaceuticals, Inc.
- 当前专利权人: ARIAD Pharmaceuticals, Inc.
- 当前专利权人地址: US MA Cambridge
- 代理商 David L. Berstein
- 主分类号: A61K31/675
- IPC分类号: A61K31/675 ; A61F2/00
摘要:
This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which:A is absent or is —O—, —S— or —NR2—;Q is absent or (if A is —O—, —S— or —NR2—) Q may be —V—, —OV—, —SV—, or —NR2V—, where V is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, such that J is linked to the cyclohexyl ring directly, through A or through VA, OVA, SVA or NR2VA; K is O or S; each occurrence of Y is independently —O—, —S—, —NR2—, or a bond linking a R5 moiety to P; each occurrence of R2 and R5 is independently an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, or H; and each occurrence of R6 is independently —PK(YR5)(YR5), —SO2(YR5) or —C(O)(YR5); so long as any R2, or R5 moiety linked directly to P is not H; wherein two R2, R5 and/or R6 moieties may be chemically linked to one another to form a ring; each occurrence of G is independently —O—, —S—, —NR2— or (M)x; each occurrence of M is independently a substituted or unsubstituted methylene moiety, and any M-M′ moiety may be saturated or unsaturated; each occurrence of x is independently an integer from 1-6; and the other variables are as defined herein.
公开/授权文献
- US20070190106A1 Phosphorus-containing compounds & uses thereof 公开/授权日:2007-08-16
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