发明授权
US07709216B2 Methods for preventing or reducing ischemia/reperfusion induced myocardial cell death
失效
预防或减少缺血/再灌注诱导心肌细胞死亡的方法
- 专利标题： Methods for preventing or reducing ischemia/reperfusion induced myocardial cell death
- 专利标题（中）： 预防或减少缺血/再灌注诱导心肌细胞死亡的方法
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申请号： US11891015申请日： 2007-08-08
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公开(公告)号： US07709216B2公开(公告)日： 2010-05-04
- 发明人: Peter Erhardt , Ambrus Toth
- 申请人： Peter Erhardt , Ambrus Toth
- 申请人地址： US MA Watertown
- 专利权人： Boston Biomedical Research Institute
- 当前专利权人： Boston Biomedical Research Institute
- 当前专利权人地址： US MA Watertown
- 代理机构： Pierce Atwood LLP
- 代理商 Kevin M. Farrell; David J. Wilson
- 主分类号： A61K39/395
- IPC分类号： A61K39/395
摘要：
Provided herein are methods relating to inhibition of PUMA function for preventing or reducing myocardial cell death. A method for preventing or reducing ischemia/reperfusion induced myocardial cell death in a human is provided as are methods for identifying pharmaceuticals which interfere with PUMA function. Also herein provided is a method for reducing stem cell death in stem cell explants wherein the explants are intended to restore cardiac efficiency following cell death in response to coronary infarct.
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