Invention Grant
US07709237B2 Crystal structure of CMY-10, a β-lactamase causing antibiotic resistance with extended-substrate spectrum
有权
CMY-10的晶体结构，具有延长底物光谱的抗生素抗性的β-内酰胺酶
- Patent Title: Crystal structure of CMY-10, a β-lactamase causing antibiotic resistance with extended-substrate spectrum
- Patent Title (中): CMY-10的晶体结构，具有延长底物光谱的抗生素抗性的β-内酰胺酶
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Application No.: US11659244Application Date: 2005-07-25
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Publication No.: US07709237B2Publication Date: 2010-05-04
- Inventor: Sang-Hee Lee , Sun-Shin Cha , Jung-Hun Lee , Ha-Il Jung
- Applicant: Sang-Hee Lee , Sun-Shin Cha , Jung-Hun Lee , Ha-Il Jung
- Assignee: Myongji University Industry and Academia Cooperation
- Current Assignee: Myongji University Industry and Academia Cooperation
- Agency: Edwards Angell Palmer & Dodge LLP
- Agent Kongsik Kim
- Priority: KR10-2004-0058283 20040726; KR10-2005-0041342 20050517
- International Application: PCT/KR2005/002400 WO 20050725
- International Announcement: WO2006/011736 WO 20060202
- Main IPC: C12N9/00
- IPC: C12N9/00 ; C12N9/14 ; C12N9/78 ; C12N9/86 ; C07K14/00 ; C07K17/00
Abstract:
The present invention related to a method for crystallizing a CMY-10 being a β-lactamase with extended-substrate spectrum, a crystal of CMY-10, and a crystal structure of CMY-10. With utilization of three-dimensional structure of CMY-10 protein provided by the present invention, it is possible to develop novel antibiotics or inhibitors that can prevent an emergence of resistance bacteria appeared by plasmidic class C β-lactamases having extended-substrate specificity.
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