发明授权
US07713972B2 Imidazotriazinone derivatives as PDE 7 (phosphodiesterase 7) inhibitors
失效
咪唑并三嗪酮衍生物作为PDE 7（磷酸二酯酶7）抑制剂
- 专利标题： Imidazotriazinone derivatives as PDE 7 (phosphodiesterase 7) inhibitors
- 专利标题（中）： 咪唑并三嗪酮衍生物作为PDE 7（磷酸二酯酶7）抑制剂
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申请号： US10560503申请日： 2004-06-11
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公开(公告)号： US07713972B2公开(公告)日： 2010-05-11
- 发明人: Hidekazu Inoue , Hidenobu Murafuji , Yasuhiro Hayashi
- 申请人： Hidekazu Inoue , Hidenobu Murafuji , Yasuhiro Hayashi
- 申请人地址： JP Tokyo
- 专利权人： Asubio Pharma Co., Ltd.
- 当前专利权人： Asubio Pharma Co., Ltd.
- 当前专利权人地址： JP Tokyo
- 代理机构： Hunton & Williams LLP
- 优先权： JP2003-170095 20030613
- 国际申请： PCT/JP2004/008642 WO 20040611
- 国际公布： WO2004/111053 WO 20041223
- 主分类号： A61K31/53
- IPC分类号： A61K31/53 ; A01N43/64 ; A01N43/66 ; C07D253/08 ; C07D487/00
摘要：
The present invention provides the compounds inhibiting PDE 7 selectively, and therefore, enhances cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic disease, inflammatory disease or immunologic disease. The compound is imidazotriazinone compound represented by the following formula (IA) or (IB): especially, R1 is cyclohexyl group, R2 is methyl group; R3 is a hydrogen atom; nitro group; cyano group; a halogen atom; heteroaryl group; substituted or unsubstituted C1-C6 alkyl group; substituted or unsubstituted C2-C6 alkenyl group; saturated or unsaturated heterocycloalkyl group which is substituted or unsubstituted; a group: —NR5R6, —C(O)R7, —SO2R7, —OR8, —NR8COR7, —NR8S02R7; A is CR4; and B is CH.
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