发明授权
- 专利标题： Mammalian tumor susceptibility gene products and their uses
- 专利标题（中）： 哺乳动物肿瘤易感基因产物及其用途
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申请号： US10053975申请日： 2002-01-18
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公开(公告)号： US07714108B2公开(公告)日： 2010-05-11
- 发明人: Limin Li , Stanley N. Cohen
- 申请人： Limin Li , Stanley N. Cohen
- 申请人地址： US CA Palo Alto
- 专利权人： The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人： The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人地址： US CA Palo Alto
- 代理机构： Berenato & White
- 代理商 Steven B. Kelber
- 主分类号： C07K16/00
- IPC分类号： C07K16/00 ; A61K39/395
摘要：
The present invention provides methods and compositions for regulating ubiquitination in a cell. In particular, the present invention provides purified polypeptides comprising an ubiquitination-regulating domain. The invention also provides methods of using such polypeptides for screening for agents, for producing antibodies, and for treatment of diseases, e.g., proliferative diseases, neurodegenerative diseases, autoimmune diseases, metabolic disease and developmental abnormalities. The invention further provides antibodies that bind an ubiquitination-regulating domain and agents and antibodies that regulate ubiquitination in cells, e.g., by modulating the interaction between a TSG101 protein and an MDM2 protein.