发明授权
- 专利标题： Humanized anti-IL-1 beta antibodies
- 专利标题（中）： 人源化抗IL-1β抗体
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申请号： US12428558申请日： 2009-04-23
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公开(公告)号： US07714120B2公开(公告)日： 2010-05-11
- 发明人: Craig Duane Dickinson , Alain Philippe Vasserot , Jeffry Dean Watkins , Jirong Lu
- 申请人： Craig Duane Dickinson , Alain Philippe Vasserot , Jeffry Dean Watkins , Jirong Lu
- 申请人地址： US CA San Diego
- 专利权人： Applied Molecule Evolution, Inc.
- 当前专利权人： Applied Molecule Evolution, Inc.
- 当前专利权人地址： US CA San Diego
- 代理商 Andrea M. Castetter
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C12P21/06 ; C12N15/74
摘要：
The present invention encompasses isolated antibodies, or antigen-binding portions thereof, that specifically bind mature human IL-1 Beta. These antibodies, or antigen-binding portions thereof, generally exhibit high binding affinities (low kooff values), reduced deamidation compared to the native antibody, and can be used to treat various diseases such as rheumatoid arthritis, osteoarthritis, or neuroinflammation.
公开/授权文献
- US20090209004A1 HUMAN IL-1 BETA ANTAGONISTS 公开/授权日：2009-08-20
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