发明授权
US07718183B2 Proteins with repetitive bacterial-Ig-like (big) domains present in Leptospira species
有权
在钩端螺旋体属物种中存在重复的细菌Ig样（大）结构域的蛋白质
- 专利标题： Proteins with repetitive bacterial-Ig-like (big) domains present in Leptospira species
- 专利标题（中）： 在钩端螺旋体属物种中存在重复的细菌Ig样（大）结构域的蛋白质
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申请号： US11332464申请日： 2006-01-17
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公开(公告)号： US07718183B2公开(公告)日： 2010-05-18
- 发明人: Albert I. Ko , Mitermayer Galvão Reis , Julio Henrique Rosa Croda , Isadora Cristina Siqueira , David A. Haake , James Matsunaga , Lee W. Riley , Michele Barocchi , Tracy Ann Young
- 申请人： Albert I. Ko , Mitermayer Galvão Reis , Julio Henrique Rosa Croda , Isadora Cristina Siqueira , David A. Haake , James Matsunaga , Lee W. Riley , Michele Barocchi , Tracy Ann Young
- 申请人地址： US DC Washington US CA Oakland US NY Ithaca BR Rio de Janeiro
- 专利权人： The United States of America represented by the Department of Veterans Affairs,The Regents of the University of California,Cornell Research Foundation, Inc.,Fundação Oswaldo Cruz—FIOCRUZ
- 当前专利权人： The United States of America represented by the Department of Veterans Affairs,The Regents of the University of California,Cornell Research Foundation, Inc.,Fundação Oswaldo Cruz—FIOCRUZ
- 当前专利权人地址： US DC Washington US CA Oakland US NY Ithaca BR Rio de Janeiro
- 代理机构： Klarquist Sparkman, LLP.
- 主分类号： A61K39/002
- IPC分类号： A61K39/002
摘要：
The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.
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