发明授权
US07723382B2 Process for preparing nitrooxyalkyl substituted esters of carboxylic acids, intermediates useful in said process and preparation thereof
失效
制备硝基氧基烷基取代的羧酸酯的方法，可用于所述方法的中间体及其制备方法
- 专利标题： Process for preparing nitrooxyalkyl substituted esters of carboxylic acids, intermediates useful in said process and preparation thereof
- 专利标题（中）： 制备硝基氧基烷基取代的羧酸酯的方法，可用于所述方法的中间体及其制备方法
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申请号： US10522986申请日： 2003-08-06
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公开(公告)号： US07723382B2公开(公告)日： 2010-05-25
- 发明人: Piero del Soldato , Giancarlo Santus , Francesca Benedini
- 申请人： Piero del Soldato , Giancarlo Santus , Francesca Benedini
- 申请人地址： FR Sophia Antipolis - Valbonne
- 专利权人： Nicox S.A.
- 当前专利权人： Nicox S.A.
- 当前专利权人地址： FR Sophia Antipolis - Valbonne
- 代理机构： Arent Fox LLP
- 优先权： ITMI2002A1861 20020829
- 国际申请： PCT/EP03/08700 WO 20030806
- 国际公布： WO2004/020385 WO 20040311
- 主分类号： A61K31/21
- IPC分类号： A61K31/21 ; A61K31/40 ; C07C203/04 ; C07C69/00
摘要：
The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of a drug and R1-R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independently an integer from 0 to 6, and p is 0 or 1, and X is O, S, SO, SO2, NR13 or PR13 or an aryl, heteroaryl group, said process comprising reacting a compound of formula (B) R—COOZ (B) wherein R is as defined above and Z is hydrogen or a cation selected from: Li+, Na+, K+, Ca++, Mg++, tetralkylammonium, tetralkylphosphonium, with a compound of formula (C), as reported in the description, wherein R1-R12 and m, n, o, p, q, r, s are as defined above and Y is a suitable leaving group.
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