发明授权
US07723477B2 Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
有权
用于抑制Wnt依赖性实体瘤细胞生长的组合物和方法
- 专利标题： Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
- 专利标题（中）： 用于抑制Wnt依赖性实体瘤细胞生长的组合物和方法
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申请号： US11589931申请日： 2006-10-31
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公开(公告)号： US07723477B2公开(公告)日： 2010-05-25
- 发明人: Austin Gurney , John Lewicki , Sanjeev Satyal , Timothy Hoey
- 申请人： Austin Gurney , John Lewicki , Sanjeev Satyal , Timothy Hoey
- 申请人地址： US CA Redwood City
- 专利权人： OncoMed Pharmaceuticals, Inc.
- 当前专利权人： OncoMed Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Redwood City
- 代理机构： Sterne, Kessler, Goldstein & Fox P.L.L.C.
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K1/00 ; C07K14/00 ; C07K17/00 ; C07K2/00 ; C07K4/00 ; C07K5/00 ; C07K7/00 ; C07K16/00
摘要：
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides a soluble FZD receptor comprising an extracellular domain of a human FZD receptor that inhibits growth of tumor cells. The present invention still further provides a soluble receptor comprising a Fri domain of a human FZD receptor that binds a ligand of a human FZD receptor and said soluble receptor is capable of inhibiting tumor growth. The present invention still further provides a method of treating cancer comprising administering a soluble FZD receptor comprising for example, either an extracellular domain of a human FZD receptor or a Fri domain of a human FZD receptor, in an amount effective to inhibit tumor growth.