发明授权
US07727989B2 4-benzimidazol-2-yl-pyridazine-3-one-derivatives, production and use thereof in medicaments
有权
4-苯并咪唑-2-基 - 哒嗪-3-酮衍生物，其在药物中的制备和应用
- 专利标题： 4-benzimidazol-2-yl-pyridazine-3-one-derivatives, production and use thereof in medicaments
- 专利标题（中）： 4-苯并咪唑-2-基 - 哒嗪-3-酮衍生物，其在药物中的制备和应用
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申请号： US11467639申请日： 2006-08-28
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公开(公告)号： US07727989B2公开(公告)日： 2010-06-01
- 发明人: Karl Schoenafinger , Swen Hoelder , David William Will , Hans Matter , Guenter Mueller , Martin Bossart
- 申请人： Karl Schoenafinger , Swen Hoelder , David William Will , Hans Matter , Guenter Mueller , Martin Bossart
- 申请人地址： DE Frankfurt am Main
- 专利权人： Sanofi-Aventis Deutschland GmbH
- 当前专利权人： Sanofi-Aventis Deutschland GmbH
- 当前专利权人地址： DE Frankfurt am Main
- 代理商 Jiang Lin
- 优先权： DE102004010194 20040302
- 主分类号： A61K31/501
- IPC分类号： A61K31/501 ; C07D401/14 ; C07D413/14 ; A61K31/5355 ; A61K31/553
摘要：
The present invention relates to kinase inhibitor compounds and derivatives thereof as well as compositions comprising them consisting of the structure of formula I: Wherein R1, R2, A, B, D and E are defined herein. These 4-benzimidazol-2-ylpyridazin-3-ones and their derivatives and compositions comprising them are useful in the treatment of neurological disorders such as Alzheimers' disease, Parkinsons' disease, obesity, hypertension and the like. These pyridazinone derivatives particularly inhibit the metabolic activity of glycogen synthase kinase-3 β (GSK-3β) which is believed to cause the neurodegeneration that results in these diseases.