发明授权
US07732157B1 Soluble epidermal growth factor receptor-like proteins and their uses in cancer detection methods
有权
可溶性表皮生长因子受体样蛋白及其在癌症检测方法中的应用
- 专利标题： Soluble epidermal growth factor receptor-like proteins and their uses in cancer detection methods
- 专利标题（中）： 可溶性表皮生长因子受体样蛋白及其在癌症检测方法中的应用
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申请号： US09676380申请日： 2000-09-29
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公开(公告)号： US07732157B1公开(公告)日： 2010-06-08
- 发明人: Andre T. Baron , Nita J. Maihle
- 申请人： Andre T. Baron , Nita J. Maihle
- 申请人地址： US MN Rochester
- 专利权人： Tumor Biology Investment Group
- 当前专利权人： Tumor Biology Investment Group
- 当前专利权人地址： US MN Rochester
- 代理机构： Cohen & Grigsby, P.C.
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; G01N33/53 ; G01N33/574
摘要：
The present invention relates to the discovery of soluble isoforms of an Epidermal Growth Factor Receptor, or sErbB 1/HER1 variants, the provision of the sequences of nucleic acids encoding these isoforms, purified recombinant proteins, novel antibodies specific for these isoforms, and the use of immunoassay and gene expression assay techniques to measure the concentration of these gene products in a patient biological sample. The present invention also provides methods for determining the presence of an ovarian carcinoma in the patient by assaying the concentration of soluble EGFR/ErbB1 variants in a biological sample from a patient.
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