发明授权
US07732162B2 Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
有权
用于治疗神经变性疾病的谷氨酰胺环化酶抑制剂
- 专利标题： Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
- 专利标题（中）： 用于治疗神经变性疾病的谷氨酰胺环化酶抑制剂
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申请号： US11685881申请日： 2007-03-14
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公开(公告)号： US07732162B2公开(公告)日： 2010-06-08
- 发明人: Torsten Hoffman , Stephan Schilling , Andre J. Niestroj , Hans-Ulrich Demuth , Ulrich Heiser , Mirko Buchholz
- 申请人： Torsten Hoffman , Stephan Schilling , Andre J. Niestroj , Hans-Ulrich Demuth , Ulrich Heiser , Mirko Buchholz
- 申请人地址： DE Halle (Salle)
- 专利权人： Probiodrug AG
- 当前专利权人： Probiodrug AG
- 当前专利权人地址： DE Halle (Salle)
- 代理机构： Sonnenschein Nath & Rosenthal LLP
- 主分类号： C12Q1/34
- IPC分类号： C12Q1/34
摘要：
The present invention provides novel physiological substrates of mammalian glutaminyl cyclase (QC, EC 2.3.2.5), new effectors of QC, methods for screening for such effectors, and the use of such effectors and pharmaceutical compositions comprising such effectors for the treatment of conditions that can be treated by modulation of QC-activity. Preferred compositions additionally comprise inhibitors of DP IV or DP IV-like enzymes for the treatment or alleviation of conditions that can be treated by modulation of QC- and DP IV-activity.
公开/授权文献
- US20070191366A1 USE OF EFFECTORS OF GLUTAMINYL AND GLUTAMATE CYCLASES 公开/授权日：2007-08-16