发明授权
US07732421B2 RNAI-mediated inhibition of tumor necrosis factor α-related conditions
有权
RNAI介导的抑制肿瘤坏死因子α相关病症
- 专利标题： RNAI-mediated inhibition of tumor necrosis factor α-related conditions
- 专利标题（中）： RNAI介导的抑制肿瘤坏死因子α相关病症
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申请号： US11750262申请日： 2007-05-17
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公开(公告)号： US07732421B2公开(公告)日： 2010-06-08
- 发明人: John M. Yanni , Jon E. Chatterton , Diane Michelle Senchyna , Daniel A. Gamache , Steven T. Miller
- 申请人： John M. Yanni , Jon E. Chatterton , Diane Michelle Senchyna , Daniel A. Gamache , Steven T. Miller
- 申请人地址： US TX Fort Worth
- 专利权人： Alcon Research, Ltd.
- 当前专利权人： Alcon Research, Ltd.
- 当前专利权人地址： US TX Fort Worth
- 代理商 Jason J. Derry
- 主分类号： A01N43/04
- IPC分类号： A01N43/04 ; A61K31/70
摘要：
RNA interference is provided for inhibition of tumor necrosis factor α (TNFα) by silencing TNFα cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNFα converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNFα targets, in particular, is useful for treating patients having a TNFα-related condition or at risk of developing a TNFα-related condition such as the ocular conditions dry eye, allergic conjunctivitis, or ocular inflammation, or such as dermatitis, rhinitis, or asthma, for example.
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