发明授权
US07732493B2 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
失效
2-取代的D-异孕烯-1,3,5（10） - 三烯作为17型和β-羟基类固醇脱氢酶1型的抑制剂
- 专利标题： 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
- 专利标题（中）： 2-取代的D-异孕烯-1,3,5（10） - 三烯作为17型和β-羟基类固醇脱氢酶1型的抑制剂
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申请号： US12192446申请日： 2008-08-15
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公开(公告)号： US07732493B2公开(公告)日： 2010-06-08
- 发明人: Alexander Hillisch , Olaf Peters , Christian Gege , Wilko Regenhardt , Gabriele Moeller , Dominga Deluca , Jerzy Adamski , Walter Elger , Birgitt Schneider
- 申请人： Alexander Hillisch , Olaf Peters , Christian Gege , Wilko Regenhardt , Gabriele Moeller , Dominga Deluca , Jerzy Adamski , Walter Elger , Birgitt Schneider
- 申请人地址： DE Berlin
- 专利权人： Bayer Schering Pharma Aktiengesellschaft
- 当前专利权人： Bayer Schering Pharma Aktiengesellschaft
- 当前专利权人地址： DE Berlin
- 代理机构： Millen, White, Zelano & Branigan, P.C.
- 优先权： DE102004032673 20040702
- 主分类号： A61K31/12
- IPC分类号： A61K31/12 ; A61K31/56 ; C07J1/00 ; C07C49/00
摘要：
The invention relates to new 2-substituted D-homo-estra-1,3,5(10)-trienes of general formula I in which R2 means a C1-C8-alkyl group, a C1-C8-alkyloxy group or a halogen atom, R13 means a hydrogen atom or a methyl group, R17 means a hydrogen atom or a fluorine atom, as well as their pharmaceutically acceptable salts, their manufacture and use as medicaments for prophylaxis and therapy of estrogen-dependent diseases that can be influenced by inhibition of 17β-hydroxy steroid dehydro-genase type 1.
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