发明授权
US07732596B2 Fused heterocycle derivative, medicinal composition containing the same, and medicinal use thereof
有权
稠合的杂环衍生物,含有它们的药物组合物及其医药用途
- 专利标题: Fused heterocycle derivative, medicinal composition containing the same, and medicinal use thereof
- 专利标题(中): 稠合的杂环衍生物,含有它们的药物组合物及其医药用途
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申请号: US10591403申请日: 2005-03-03
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公开(公告)号: US07732596B2公开(公告)日: 2010-06-08
- 发明人: Nobuhiko Fushimi , Hideki Fujikura , Masayuki Isaji
- 申请人: Nobuhiko Fushimi , Hideki Fujikura , Masayuki Isaji
- 申请人地址: JP Nagano
- 专利权人: Kissei Pharmaceutical Co., Ltd.
- 当前专利权人: Kissei Pharmaceutical Co., Ltd.
- 当前专利权人地址: JP Nagano
- 代理机构: Sughrue Mion, PLLC
- 优先权: JP2004-061429 20040304
- 国际申请: PCT/JP2005/004152 WO 20050303
- 国际公布: WO2005/085265 WO 20050915
- 主分类号: C07H7/06
- IPC分类号: C07H7/06 ; C07H7/04 ; A61K31/7042
摘要:
The present invention provides nitrogen-containing fused cyclic derivatives represented by the following general formula or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications or obesity, in the formula one of R1 and R4 represents a group represented by the following general formula (S) (in which R5 and R6 represent H, OH, a halogen atom, etc.; Q represents an alkylene group etc.; and ring A represents an aryl group etc.), and the other represents H, OH, an amino group, etc.; R2 and R3 represent H, OH, an amino group, a halogen atom, and an optionally substituted alkyl group, etc.; A1 represents O, S, etc.; A2 represents CH or N; G represents a group represented by the following general formula (G-1) or (G-2) (E1 represents H, F or OH; and E2 represents H, F, a methyl group, etc.), and pharmaceutical compositions comprising the same, and pharmaceutical uses thereof.
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