发明授权
US07737173B2 Indole-3-carboxylic acid amide, ester, thioamide and thiol ester compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
有权
吲哚-3-羧酸酰胺，酯，硫代酰胺和含有具有鞘氨醇-1-磷酸（S1P）受体拮抗剂生物活性的芳基或杂芳基的硫醇酯化合物
- 专利标题： Indole-3-carboxylic acid amide, ester, thioamide and thiol ester compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
- 专利标题（中）： 吲哚-3-羧酸酰胺，酯，硫代酰胺和含有具有鞘氨醇-1-磷酸（S1P）受体拮抗剂生物活性的芳基或杂芳基的硫醇酯化合物
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申请号： US11675168申请日： 2007-02-15
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公开(公告)号： US07737173B2公开(公告)日： 2010-06-15
- 发明人: Richard L. Beard , John E. Donello , Haiqing Yuan , Diana F. Colon , Tien Duong , Xiaoxia Liu , Yihui Hu
- 申请人： Richard L. Beard , John E. Donello , Haiqing Yuan , Diana F. Colon , Tien Duong , Xiaoxia Liu , Yihui Hu
- 申请人地址： US CA Irvine
- 专利权人： Allergan, Inc.
- 当前专利权人： Allergan, Inc.
- 当前专利权人地址： US CA Irvine
- 代理机构： Allergan, Inc.
- 代理商 Kevin J. Forrestal; John E. Wurst
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; C07D209/42
摘要：
The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1-phosphate receptor agonist and or antagonist biological activity: and wherein the variables Y, R4, n, A, X, Z, R1, o, R3, R2 and p are as defined in the specification. These compounds are useful for treating a disease or condition selected from the group consisting of glaucoma, dry eye, angiogenesis, cardiovascular conditions and diseases, and wound healing.
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