发明授权
- 专利标题： Variant Fc regions
- 专利标题（中）： 变异Fc区
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申请号： US11572634申请日： 2005-07-18
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公开(公告)号： US07740847B2公开(公告)日： 2010-06-22
- 发明人: Barrett Allan , Weidong Jiang , Ying Tang , Jeffry Dean Watkins
- 申请人： Barrett Allan , Weidong Jiang , Ying Tang , Jeffry Dean Watkins
- 申请人地址： US CA San Diego
- 专利权人： Applied Molecular Evolution, Inc.
- 当前专利权人： Applied Molecular Evolution, Inc.
- 当前专利权人地址： US CA San Diego
- 代理商 Robert L. Sharp; MaryAnn Wiskerchen
- 国际申请： PCT/US2005/025276 WO 20050718
- 国际公布： WO2006/020114 WO 20060223
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/28 ; C07K16/30 ; C12N15/13 ; C12N15/63 ; C12N15/16
摘要：
The present invention provides humanized anti-CD20 antibodies comprising a human IgG1 Fc region comprising an isoleucine at position 247 and a glutamine at position 339 as well as nucleic acids encoding the antibodies and methods of using the antibodies for treating lymphoma. Furthermore, the invention provides compositions comprising the antibodies and methods of producing them.
公开/授权文献
- US20070224188A1 Variant Fc Regions 公开/授权日：2007-09-27
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