发明授权
US07741035B2 Use of gene expression profiling to predict survival in cancer patient
有权
使用基因表达谱来预测癌症患者的存活
- 专利标题： Use of gene expression profiling to predict survival in cancer patient
- 专利标题（中）： 使用基因表达谱来预测癌症患者的存活
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申请号： US11147829申请日： 2005-06-08
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公开(公告)号： US07741035B2公开(公告)日： 2010-06-22
- 发明人: John D. Shaughnessy , Bart Barlogie , Fenghuang Zhan
- 申请人： John D. Shaughnessy , Bart Barlogie , Fenghuang Zhan
- 申请人地址： US AR Little Rock
- 专利权人： Board of Trustees of the University of Arkansas
- 当前专利权人： Board of Trustees of the University of Arkansas
- 当前专利权人地址： US AR Little Rock
- 代理商 Benjamin Aaron Adler
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; G01N33/48
摘要：
Gene expression profiling in multiple myeloma patients identifies genes that distinguish between patients with subsequent early death or long survival after treatment. Poor survival is linked to over-expression of genes such as ASPM, OPN3 and CKS1B which are located in chromosome 1q. Given the frequent amplification of 1q in many cancers, it is possible that these genes can be used as powerful prognostic markers and therapeutic targets for multiple myeloma and other cancer.
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