发明授权
US07741351B2 Compounds which potentiate glutamate receptor and uses thereof in medicine
失效
增强谷氨酸受体的药物及其在药物中的应用
- 专利标题: Compounds which potentiate glutamate receptor and uses thereof in medicine
- 专利标题(中): 增强谷氨酸受体的药物及其在药物中的应用
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申请号: US11573368申请日: 2005-08-05
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公开(公告)号: US07741351B2公开(公告)日: 2010-06-22
- 发明人: Kevin Michael Thewlis , Simon Edward Ward
- 申请人: Kevin Michael Thewlis , Simon Edward Ward
- 申请人地址: GB Greenford, Middlesex
- 专利权人: Glaxo Group Limited
- 当前专利权人: Glaxo Group Limited
- 当前专利权人地址: GB Greenford, Middlesex
- 代理商 James M. Kanagy; Edward R. Gimmi; Charles M. Kinzig
- 优先权: GB0417709.3 20040809
- 国际申请: PCT/EP2005/008563 WO 20050805
- 国际公布: WO2006/015829 WO 20060216
- 主分类号: A61K31/425
- IPC分类号: A61K31/425 ; A61K31/40 ; A61K31/275 ; A61K31/17
摘要:
This case discloses compounds of formula (I) wherein R1 is C1-6alkyl, haloC1-6alkyl, C2-6alkenyl, amino, monoC1-4alkylamino or diC1-4alkylamino; R2 and R3, which may be the same or different, are hydrogen, halogen, C1-6alkyl, haloC1-6alkyl, C1-4alkoxy, haloC1-4alkoxy, cyano or amino; each R4, which may be the same or different, is C1-6alkyl, halogen, haloC1-6alkyl, C1-4alkoxy, haloC1-4alkoxy, cyano, nitro or amino; p is 0, 1 or 2; each R5, which may be the same or different, is C1-6alkyl, halogen, haloC1-6alkyl, C1-4alkoxy, haloC1-4alkoxy, cyano, nitro or amino; q is 0, 1 or 2; R6 is —NR6aSO2R6b, —NR6aC(═O)R6b, —NR6a(C═O)N(R6c)2, —(C═O)R6d, —CH2NR6aSO2R6b, —CH2NR6aC(═O)R6b, CH2NR6a(C═O)N(R6c)2 or —CH2(C═O)R6d; where R6a and each R6c, which may be the same or different, is hydrogen or C1-6alkyl; R6b and R6d are C1-6alkyl or haloC1-6alkyl; or R6a and R6b, or R6a and R6c, together with the interconnecting atoms, may form a 5- or 6-membered ring; n is 1 or 2; and R7 and R8, which may be the same or different, are hydrogen, halogen, C1-6alkyl, haloC1-6alkyl, C1-4alkoxy, haloC1-4alkoxy, cyano or amino. It also discloses methods for preparing the compounds and their use in therapy such as treating schizophrenia.