发明授权
US07741473B2 Process for the preparation of 4,6-disubstituted-tetrahydro-furo, thieno, pyrrolo and cyclopenta-[3,4][1,3]dioxoles
失效
制备4,6-二取代 - 四氢 - 呋喃，噻吩并，吡咯并环戊烷并[3,4] [1,3]二氧杂环戊烯的方法
![Process for the preparation of 4,6-disubstituted-tetrahydro-furo, thieno, pyrrolo and cyclopenta-[3,4][1,3]dioxoles](/docs/US/2010-06-22/US07741473B2/abs.jpg.600x600.jpg)
- 专利标题： Process for the preparation of 4,6-disubstituted-tetrahydro-furo, thieno, pyrrolo and cyclopenta-[3,4][1,3]dioxoles
- 专利标题（中）： 制备4,6-二取代 - 四氢 - 呋喃，噻吩并，吡咯并环戊烷并[3,4] [1,3]二氧杂环戊烯的方法
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申请号： US11393374申请日： 2006-03-30
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公开(公告)号： US07741473B2公开(公告)日： 2010-06-22
- 发明人: Paul S. Watson , James G. Douglass, III , Bob Suchozak , Subramanian Pandiaraju , Craig E. Dixon , Daniel Levin
- 申请人： Paul S. Watson , James G. Douglass, III , Bob Suchozak , Subramanian Pandiaraju , Craig E. Dixon , Daniel Levin
- 申请人地址： US NC Durham
- 专利权人： Inspire Pharmaceuticals, Inc.
- 当前专利权人： Inspire Pharmaceuticals, Inc.
- 当前专利权人地址： US NC Durham
- 代理机构： Howrey LLP
- 代理商 Viola T. Kung
- 主分类号： C07H19/067
- IPC分类号： C07H19/067 ; C07H19/167
![Process for the preparation of 4,6-disubstituted-tetrahydro-furo, thieno, pyrrolo and cyclopenta-[3,4][1,3]dioxoles](/abs-image/US/2010/06/22/US07741473B2/abs.jpg.150x150.jpg)
摘要：
The present invention is directed to a processes for the synthesis of trans isomer of 4,6-disubstituted-tetrahydro-furo, thieno, pyrrolo and cyclopenta-[3,4][1,3]dioxoles (Formula I). The process comprises the steps of: (a) obtaining a compound of Formula II, which is a mixture of cis and trans-diastereomers, and (b) chemically decomposing the compound of Formula II in a solution comprising a solvent and an acid that is a hydrogen donor or an electron pair acceptor, whereby the cis diastereomer is decomposed and the compound of Formula I is obtained. The compounds prepared by the present invention are useful in treating diseases or conditions associated with platelet aggregation and/or platelet activation.
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