发明授权
- 专利标题: Human antibodies interacting with HIV gp41
- 专利标题(中): 人类抗体与HIV gp41相互作用
-
申请号: US11628164申请日: 2005-05-31
-
公开(公告)号: US07744887B2公开(公告)日: 2010-06-29
- 发明人: John W. Shiver , Michael D. Miller , Romas Geleziunas , Daria J. Hazuda , Peter S. Kim , Debra M. Eckert , Michael J. Root , Simon N. Lennard , Elisabetta Bianchi
- 申请人: John W. Shiver , Michael D. Miller , Romas Geleziunas , Daria J. Hazuda , Peter S. Kim , Debra M. Eckert , Michael J. Root , Simon N. Lennard , Elisabetta Bianchi
- 申请人地址: US NJ Rahway US MA Cambridge GB Cambridge, Cambridgeshire IT Pomesia, Rome
- 专利权人: Merck & Co., Inc.,Whitehead Insitute of Biomedical Research,MedImmune Limited,Istitute di Ricerche di Biologia Molecolare P. Angeletti S.p.A.
- 当前专利权人: Merck & Co., Inc.,Whitehead Insitute of Biomedical Research,MedImmune Limited,Istitute di Ricerche di Biologia Molecolare P. Angeletti S.p.A.
- 当前专利权人地址: US NJ Rahway US MA Cambridge GB Cambridge, Cambridgeshire IT Pomesia, Rome
- 代理商 Henry P. Wu; Sheldon O. Hober
- 国际申请: PCT/US2005/019049 WO 20050531
- 国际公布: WO2005/118887 WO 20051215
- 主分类号: A61K39/42
- IPC分类号: A61K39/42 ; G01N33/53 ; A61K39/395 ; C12P16/00
摘要:
Human scFvs are disclosed which interact with a conformational epitope along the pre-hairpin, N-helix coiled coil structure within the heptad repeat 1 (HR1) region of gp41 of HIV. These antibodies, as well as IgG conversions, are shown to neutralize diverse HIV isolates. Isolated nucleic acid molecules are also disclosed which encode relevant portions of these antibodies, as well as the purified forms of the expressed antibodies or relevant antibody fragments, such as VH and VL chains. The antibody compositions disclosed within this specification may provide for a therapeutic treatment against HIV infection by reducing viral load levels within an infected individual, thus prolonging the asymptomatic phase of HIV infection. These antibodies will also be useful in assays to identify HIV antiviral compounds as well as allowing for the identification of candidate HIV vaccines, such as HIV peptide vaccines.
公开/授权文献
- US20070248613A1 Human Antibodies Interacting with Hiv Gp41 公开/授权日:2007-10-25