发明授权
- 专利标题： Human and mammalian stem cell-derived neuron survival factors
- 专利标题（中）： 人和哺乳动物干细胞衍生的神经元存活因子
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申请号： US11840884申请日： 2007-08-17
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公开(公告)号： US07749758B2公开(公告)日： 2010-07-06
- 发明人: Tasuku Honjo , Kei Tashiro , Jun Takahashi , Hiroki Toda
- 申请人： Tasuku Honjo , Kei Tashiro , Jun Takahashi , Hiroki Toda
- 申请人地址： JP Osaka JP Kyoto
- 专利权人： Ono Pharmaceutical Co., Ltd.,Tasuku Honjo
- 当前专利权人： Ono Pharmaceutical Co., Ltd.,Tasuku Honjo
- 当前专利权人地址： JP Osaka JP Kyoto
- 代理机构： Sughrue Mion, PLLC
- 优先权： JPP.2001-325189 20011023
- 主分类号： C12N5/02
- IPC分类号： C12N5/02 ; C12N5/06 ; C12N5/08
摘要：
The present invention relates to human, rat and mouse stem cell-derived neuron survival factor polypeptides (SDNSF), a process for producing them, cDNA encoding SDNSF, a vector comprising the cDNA, host cells transformed by the vector, an antibody against SDNSF, pharmaceutical compositions containing SDNSF or the antibody, a method of assaying SDNSF, a reagent for assaying SDNSF, and a screening method using SDNSF. The polypeptides are effective in the survival of nerve cells and, therefore, efficacious in treating injury to the central nerve system caused by brain infarction, brain hemorrhage, spinal cord injury, etc.
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