发明授权
US07750029B2 Remedy for overactive bladder comprising acetic acid anilide derivative as the active ingredient
有权
包括醋酸苯胺衍生物作为活性成分的膀胱活动过度的补救措施
- 专利标题: Remedy for overactive bladder comprising acetic acid anilide derivative as the active ingredient
- 专利标题(中): 包括醋酸苯胺衍生物作为活性成分的膀胱活动过度的补救措施
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申请号: US10534290申请日: 2003-11-04
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公开(公告)号: US07750029B2公开(公告)日: 2010-07-06
- 发明人: Toshiyuki Takasu , Shuichi Sato , Masashi Ukai , Tatsuya Maruyama
- 申请人: Toshiyuki Takasu , Shuichi Sato , Masashi Ukai , Tatsuya Maruyama
- 申请人地址: JP Tokyo
- 专利权人: Astellas Pharma Inc.
- 当前专利权人: Astellas Pharma Inc.
- 当前专利权人地址: JP Tokyo
- 代理机构: Sughrue Mion, PLLC
- 优先权: JP2002-323792 20021107
- 国际申请: PCT/JP03/14065 WO 20031104
- 国际公布: WO2004/041276 WO 20040521
- 主分类号: A61K31/426
- IPC分类号: A61K31/426 ; A61P13/10
摘要:
(R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetic acid anilide or its salt shows a potent bladder relaxation effect in “isolated rat bladder smooth muscle relaxation test”, dose-dependently lowers the contraction frequency of rhythmic bladder contractions in “rat rhythmic bladder contraction measurement test” and, moreover, prolongs the urination intervals in “urination functions measurement test on cyclophosphamide-induced overactive bladder model rat”. Owing to these effects, the above compound is useful as a remedy for ovaractive bladder.