发明授权
- 专利标题: Local drug delivery
- 专利标题(中): 当地药物递送
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申请号: US10842416申请日: 2004-05-11
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公开(公告)号: US07754272B2公开(公告)日: 2010-07-13
- 发明人: Lee Rowan , Peter William Stratford , Alistair Stewart Taylor , Terrence Albert Vick
- 申请人: Lee Rowan , Peter William Stratford , Alistair Stewart Taylor , Terrence Albert Vick
- 申请人地址: GB Surrey
- 专利权人: Biocompatibles IK Limited
- 当前专利权人: Biocompatibles IK Limited
- 当前专利权人地址: GB Surrey
- 代理机构: Sughrue Mion, PLLC
- 优先权: EP99304140 19990527; EP99304584 19990611
- 主分类号: B05D3/02
- IPC分类号: B05D3/02 ; A61F2/06
摘要:
An implant having a coating comprising a polymer matrix is swollen in a pharmaceutical solution whereby pharmaceutically active compound is imbibed into the polymer matrix. When the product is implanted, release of the pharmaceutically active compound from the coating takes place. The polymer is preferably formed from ethylenically unsaturated monomers including a zwitterionic monomer, most preferably 2-methacryloyloxyethyl-2′-trimethylammoniumethyl-phosphate inner salt. The monomers from which the polymer is formed may further include surface binding monomers, such as hydrophobic group containing monomers, and crosslinkable monomers, the content of which may be used to control the swellability. Preferably the implant is a stent and the coating of polymer on the exterior wall surface is thicker than the coating of polymer on the interior surface. Release of the drug may be controlled by selection of comonomers. The implant is suitably a stent for use in the cardiovascular system.
公开/授权文献
- US20040208985A1 Local drug delivery 公开/授权日:2004-10-21
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