A semiconductor device includes a semiconductor substrate, a monocrystalline channel region of a first conductivity type formed on the surface of the semiconductor substrate, a gate electrode formed on the channel region via a gate insulating film, a pair of source/drain electrodes of a second conductivity type provided on both sides of the gate electrode, metallic compound layers formed on the source/drain electrodes, stress application layers located under the respective source and drain electrodes and each having a crystal structure whose intrinsic lattice spacing is different from lattice spacing inherent in a substance constituting the source/drain electrodes, and first buried insulating regions disposed under the respective stress application layers.