The present invention relates to a method for disconnecting a transceiver from a bus in multipoint/multidrop architecture. A central processing unit (CPU) and a universal asynchronous receiver transmitter (UART) in a system are connected to a controller used for storing and transmitting data, and the controller is further connected with a bus through a transceiver that monitors/records data and a relay that connects or disconnects the transceiver from the bus. The controller comprises a signal comparator used to compare similarities and differences of data and a failure detection controller used to achieve connection or disconnection of the bus with the transceiver. In case of the transceiver's failure, the controller disconnects the transceiver from the bus to ensure that the bus does not fail to work due to breakdown of the transceiver. On the other hand, a signal feedback mechanism is also utilized for a maintenance person to shorten the time in failure detection and thus reduce enterprises' operating losses caused by breakdown of their communication equipments.