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发明授权
US07758868B2 Modified polymerases and attenuated viruses and methods of use thereof 失效
改性聚合酶和减毒病毒及其使用方法

Modified polymerases and attenuated viruses and methods of use thereof
摘要：
The invention encompasses compositions and methods relating to viral polymerases having one or more substitutions of different amino acids at conserved regions of the polymerase yields enzymes with varying rates and fidelity of replication. A universally applicable, polymerase-mechanism-based strategy for production of attenuated viruses and anti-viral vaccines is disclosed.
摘要（中）：

本发明包括与在聚合酶的保守区域具有一个或多个不同氨基酸取代的病毒聚合酶有关的组合物和方法产生具有不同的复制率和保真度的酶。 公开了用于生产减毒病毒和抗病毒疫苗的普遍适用的基于聚合酶机制的策略。

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