发明授权
US07759318B1 Identification of novel pathways, genes and promoter motifs regulating adipogenesis
失效
鉴定调节脂肪形成的新途径，基因和启动子基序
- 专利标题： Identification of novel pathways, genes and promoter motifs regulating adipogenesis
- 专利标题（中）： 鉴定调节脂肪形成的新途径，基因和启动子基序
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申请号： US11140437申请日： 2005-05-27
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公开(公告)号： US07759318B1公开(公告)日： 2010-07-20
- 发明人: Ranjan Perera , Seongjoon Koo , Nicholas M. Dean , Eric G. Marcusson
- 申请人： Ranjan Perera , Seongjoon Koo , Nicholas M. Dean , Eric G. Marcusson
- 申请人地址： US CA Carlsbad
- 专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 主分类号： A61K48/00
- IPC分类号： A61K48/00
摘要：
The present invention provides compounds, compositions, and methods for identification of motifs within regulatory regions of genes involved in adipogenesis and adipocyte differentiation. Compounds and compositions are provided for modulating expression of nuclear receptor/transcription factor-regulated genes. Methods for modulating the function of PPAR-γ as well as PPAR-γ-regulated gene promoters, and methods of using oligomeric compounds for diagnosis and treatment of diseases such as obesity and diabetes are also provided.
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