发明授权
US07759501B2 Process for producing N-monoalkyl-3-hydroxy-3-(2-thienyl) propanamine and intermediate
有权
制备N-单烷基-3-羟基-3-（2-噻吩基）丙胺和中间体的方法
- 专利标题： Process for producing N-monoalkyl-3-hydroxy-3-(2-thienyl) propanamine and intermediate
- 专利标题（中）： 制备N-单烷基-3-羟基-3-（2-噻吩基）丙胺和中间体的方法
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申请号： US10523287申请日： 2003-07-15
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公开(公告)号： US07759501B2公开(公告)日： 2010-07-20
- 发明人: Kenji Kogami , Noriyuki Hayashizaka , Syuzo Satake , Ichiro Fuseya , Hirokazu Kagano
- 申请人： Kenji Kogami , Noriyuki Hayashizaka , Syuzo Satake , Ichiro Fuseya , Hirokazu Kagano
- 申请人地址： JP Hyogo
- 专利权人： Sumitomo Seika Chemicals Co., Ltd.
- 当前专利权人： Sumitomo Seika Chemicals Co., Ltd.
- 当前专利权人地址： JP Hyogo
- 代理机构： Knobbe, Martens, Olson & Bear LLP
- 优先权： JP2002-229204 20020806
- 国际申请： PCT/JP03/08950 WO 20030715
- 国际公布： WO2004/016603 WO 20040226
- 主分类号： C07D333/20
- IPC分类号： C07D333/20 ; C07D333/22
摘要：
The present invention provides a process for producing an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine represented by General Formula (2): wherein R is C1-4 alkyl, comprising the step of reducing (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine represented by General Formula (1): wherein R is as defined above. According to the present invention, an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine which is for use as an intermediate for various pharmaceuticals can be produced in an industrially inexpensive and easy manner.
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