发明授权
- 专利标题: Antagonists of interleukin-15
- 专利标题(中): 白细胞介素15的拮抗剂
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申请号: US11805835申请日: 2007-05-23
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公开(公告)号: US07763434B2公开(公告)日: 2010-07-27
- 发明人: Kenneth H. Grabstein , Dean K. Pettit , Raymond J. Paxton
- 申请人: Kenneth H. Grabstein , Dean K. Pettit , Raymond J. Paxton
- 申请人地址: US CA Thousand Oaks
- 专利权人: Immunex Corporation
- 当前专利权人: Immunex Corporation
- 当前专利权人地址: US CA Thousand Oaks
- 代理机构: Lahive & Cockfield LLP
- 代理商 Jane E. Remillard; Jeanne M. DiGiorgio
- 主分类号: G01N33/53
- IPC分类号: G01N33/53
摘要:
Antagonists of mammalian interleukin-15 (“IL-15”) are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15Rα-subunit and that are incapable of transducing a signal through either the β- or γ-subunits of the IL-15 receptor complex. Also included are monoclonal antibodies against IL-15 that prevent IL-15 from effecting signal transduction through either the β- or γ-subunits of the IL-15 receptor complex. Methods of treating various disease states are disclosed, including treating allograft rejection and graft-versus-host disease.
公开/授权文献
- US20100015723A1 Antagonists of Interleukin-15 公开/授权日:2010-01-21
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