发明授权
- 专利标题： Variants of humanized anti-carcinoma MAb CC49
- 专利标题（中）： 人源化抗癌MAb CC49的变体
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申请号： US11776437申请日： 2007-07-11
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公开(公告)号： US07763719B2公开(公告)日： 2010-07-27
- 发明人: Syed V S. Kashmiri , Eduardo A. Padlan , Jeffrey Schlom
- 申请人： Syed V S. Kashmiri , Eduardo A. Padlan , Jeffrey Schlom
- 申请人地址： US DC Washington
- 专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人地址： US DC Washington
- 代理机构： Klarquist Sparkman, LLP.
- 主分类号： C07H21/04
- IPC分类号： C07H21/04
摘要：
The invention is directed towards mouse-human chimeric variants of CC49 monoclonal antibodies with minimal murine content. A first aspect of the invention provides CDR variants of humanized monoclonal antibody (HuCC49) in which less than all six (three heavy chain and three light chain) Complementarity Determining Regions (CDRs) of CC49 are present. A second aspect of the invention provides SDR variants of humanized monoclonal antibody (HuCC49) in which only Specificity Determining Regions (SDRs) of at least one CDR from CC49 are present. The invention is also directed towards biotechnological methods of making the variants and therapeutic methods of using the variants.
公开/授权文献
- US20080050810A1 VARIANTS OF HUMANIZED ANTI-CARCINOMA MAb CC49 公开/授权日：2008-02-28