A multi-degree-of-freedom motion mechanism comprises a first linkage unit, a second linkage unit, a driven unit, a connection block and a third linkage unit; the first linkage unit and the second linkage unit are respectively disposed with a first curved projecting section and a second curved projecting section; a driven rod of the driven unit is respectively movably coupled to the first curved projecting section and the second curved projecting section; the connection block is respectively pivotally coupled to a first pivot element of the driven unit and a second pivot element of a third linkage unit. Whereby, the driven unit can then be nimbly controlled to move up and down as well as left and right and rotate relatively to a geometric center point of the connection block through few drive mechanisms.