A system for imaging and providing therapy to one or more regions of interest is presented. The system includes an imaging and therapy catheter configured to image an anatomical region to facilitate assessing need for therapy in one or more regions within the anatomical region and delivering therapy to the one or more regions of interest within the anatomical region. The catheter includes a therapy device having a plurality of independently controllable therapy elements. The independence of the therapy elements is exploited when multiple regions are to receive therapy simultaneously or at a given catheter position within a subject.