The present invention relates to a single dose, one time use, self-destruction, auto-disabling safety syringe with an injection molded barrel. The invention successfully addresses and solves the problems of the prior art by combining the use of COC injection molding with the advantages presented by the ampoule cartridge and the traditional safety syringe all integrated into a single device. A pre-filled ampoule or barrel is molded with minimal draft enabling the syringe's piston plunger to be partially self-lubricated by the syringe's contents. The addition of an internal auto disabling coupler to the piston plunger allows the device to be used only a single time. In addition, the present invention's structure is such that its safety sleeve necessarily moves forward to cover the syringe's needle after use. The present invention's elements, as combined, solve the biocompatibility and safety problems of the prior art and provide an exact dose, prefilled, single time use, cartridge safety syringe.