Invention Grant
- Patent Title: Modulation of systemic immune responses by transplantation of hematopoietic stem cells transduced with genes encoding antigens and antigen presenting cell regulatory molecules
- Patent Title (中): 通过移植用编码抗原和抗原呈递细胞调节分子的基因转导的造血干细胞来调节全身免疫应答
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Application No.: US10471559Application Date: 2002-03-18
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Publication No.: US07767202B2Publication Date: 2010-08-03
- Inventor: Drew M. Pardoll , Linzhao Cheng , Yan Cui , Curt I Civin , Katherine Whartenby
- Applicant: Drew M. Pardoll , Linzhao Cheng , Yan Cui , Curt I Civin , Katherine Whartenby
- Applicant Address: US MD Baltimore
- Assignee: The Johns Hopkins University
- Current Assignee: The Johns Hopkins University
- Current Assignee Address: US MD Baltimore
- Agency: Foley Hoag, LLP
- International Application: PCT/US02/08411 WO 20020318
- International Announcement: WO02/074345 WO 20020926
- Main IPC: A61K48/00
- IPC: A61K48/00
Abstract:
The invention provides methods and compositions for the modulation of systemic immune responses by transplantation of hematopoietic stem cells transduced with genes encoding antigens and antigen presenting cell regulatory molecules. The invention includes bi-cistronic lentiviral expression vectors adapted for antigen expression in antigen presenting cells for use in DNA vaccines directed against pathogens and tumor antigens as well as for the treatment of autoimmune disease and for the establishment of antigen tolerance.
Public/Granted literature
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