Invention Grant
US07767677B2 Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
失效
杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途
- Patent Title: Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
- Patent Title (中): 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途
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Application No.: US11575640Application Date: 2005-09-20
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Publication No.: US07767677B2Publication Date: 2010-08-03
- Inventor: Rajender Kamboj , Zaihui Zhang , Jianmin Fu , Vishnumurthy Kodumuru , Serguei Sviridov , Kashinath Sadalapure , Shifeng Liu , Shaoyi Sun , Duanjie Hou , Nagasree Chakka
- Applicant: Rajender Kamboj , Zaihui Zhang , Jianmin Fu , Vishnumurthy Kodumuru , Serguei Sviridov , Kashinath Sadalapure , Shifeng Liu , Shaoyi Sun , Duanjie Hou , Nagasree Chakka
- Applicant Address: CA Burnaby
- Assignee: Xenon Pharmaceuticals Inc.
- Current Assignee: Xenon Pharmaceuticals Inc.
- Current Assignee Address: CA Burnaby
- Agency: Seed IP Law Group PLLC
- Agent Thong N. Trinh
- International Application: PCT/US2005/034129 WO 20050920
- International Announcement: WO2006/034440 WO 20060330
- Main IPC: C07F405/14
- IPC: C07F405/14 ; A61K31/496 ; A61K31/501 ; C07F401/14 ; A61P9/00 ; A61P3/10
Abstract:
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, V R2, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
Public/Granted literature
- US20080096895A1 Heterocyclic Derivatives and Their Use as Stearoyl-Coa Desaturase Inhibitors Public/Granted day:2008-04-24
Information query
